The Benefits of Polynucleotides for Skin Rejuvenation

By Dr. Meg Minasian, MBBS, former consultant eye surgeon, founder of The MW Clinic London

In the evolving world of regenerative aesthetics, polynucleotides have gained attention as a cutting-edge treatment for skin rejuvenation. Unlike traditional anti-ageing treatments that focus on masking the signs of ageing, polynucleotide therapy works at a deeper level, stimulating skin repair and regeneration for long-term improvement.

What Are Polynucleotides?

Polynucleotides are naturally occurring molecules derived from DNA that have powerful skin-repairing and anti-inflammatory properties. They help stimulate collagen and elastin production, improve hydration, and support cellular regeneration, making them an effective treatment for fine lines, wrinkles, dullness, and skin laxity.

Unlike dermal fillers, which add volume, polynucleotides work by revitalising the skin from within, improving overall texture, elasticity, and hydration.

How Do Polynucleotide Treatments Work?

During a treatment session, small amounts of polynucleotides are injected into the skin. Once introduced, these molecules trigger the body's natural wound-healing response, encouraging cell renewal and collagen synthesis. Over time, this leads to brighter, firmer, and healthier-looking skin.

Patients typically notice visible improvements within a few weeks, with full benefits appearing as collagen production increases. A series of treatments is often recommended for optimal results.

Who Can Benefit from Polynucleotide Treatments?

Polynucleotide therapy is particularly beneficial for those experiencing:

• ✔️ Loss of skin elasticity and firmness
• ✔️ Fine lines and wrinkles
• ✔️ Dull, dehydrated skin
• ✔️ Sun damage and environmental stress
• ✔️ Under-eye hollowness or tired-looking skin

It is suitable for all skin types and can be safely combined with other aesthetic treatments to enhance overall results.

Polynucleotides vs. Other Skin Rejuvenation Treatments

Many people considering skin rejuvenation ask how polynucleotides compare to other treatments like dermal fillers or PRP (platelet-rich plasma).

Treatment	How It Works	Considered For
Polynucleotides	Regenerates skin cells, stimulates collagen, and improves hydration	Skin quality, elasticity, hydration, under-eye rejuvenation
Dermal Fillers	Adds volume by filling specific areas	Cheek volume, deep lines, lip enhancement
PRP (Platelet-Rich Plasma)	Uses patient’s blood to stimulate healing	Acne scars, texture improvement, hair restoration

Is Polynucleotide Treatment Safe?

Yes. Polynucleotide therapy has been extensively studied and is known for its excellent safety profile. Because these molecules are naturally occurring, there is a low risk of allergic reactions or complications. Treatments are performed using fine, precise injections, ensuring minimal downtime with only mild swelling or redness, which typically resolves within 24-48 hours.

However, choosing an experienced medical professional is key to achieving optimal results and ensuring safe administration.

What to Expect from a Treatment

• ✔️ Procedure Time: ~30 minutes
• ✔️ Downtime: Minimal (redness/swelling may occur for 24-48 hours)
• ✔️ Results: Gradual improvement over several weeks
• ✔️ Best Results: Typically seen after a series of treatments

Final Thoughts: Why Polynucleotides Are the Future of Skin Regeneration

Unlike traditional aesthetic treatments that focus on short-term fixes, polynucleotides work at the cellular level, delivering long-term improvements in skin health and appearance. Whether you're looking to improve hydration, reduce fine lines, or enhance elasticity, this science-backed treatment provides a natural and effective way to achieve healthy, youthful skin without relying on artificial volume.

About the Author

Dr. Meg Minasian is a GMC-registered doctor and former consultant eye surgeon with over 30 years of medical experience. At The MW Clinic London, she specialises in regenerative aesthetic treatments, ensuring a safe and results-driven approach for every patient.